The laboratory of Professor Xiaolu Yang at the Perelman School of Medicine, the University of Pennsylvania, is seeking highly motivated postdoctoral researchers to join our dynamic and interdisciplinary team. Our research focuses on fundamental mechanisms underlying neurodegenerative diseases and cancer , with current projects concentrated in two main areas:
1. Protein quality control, aging, and neurodegenerative diseases
We have discovered two novel protein quality control (PQC) systems involving tripartite motif (TRIM) proteins and poly-Asp/Glu (polyD/E) proteins. These systems are ATP-independent and uniquely conserved—TRIM in animals and polyD/E in eukaryotes—setting them apart from classical PQC mechanisms. We are exploring their molecular mechanisms, their roles in aging and neurodegenerative diseases (including Alzheimer’s, Parkinson’s, and ALS), and their potential in therapeutic development.
2. Tumor suppression, metabolism, and autophagy
We study the regulation and function of the tumor suppressor p53, focusing on its roles in metabolic pathways essential for biosynthesis and redox balance. Our work explores how p53 functions as both a sensor and regulator of cellular metabolism. We are also identifying metabolic alterations that contribute to tumor initiation and progression. A recent extension of this work examines the role of metabolism and autophagy in stem cells, including embryonic and cancer stem cells.
For more information about our research , please see the following publications and website:
Science 381 : eadd6696 (2023); PMID: 37499037
Science Advances 8 : eabo0404 (2022); PMID: 35857842
Nature 597 : 132-137 (2021); PMID: 34408321
Nature Cell Biology 23 : 978–991 (2021); PMID: 34497368
Cell Metabolism 33 : 94-109 (2021); PMID: 33159852
Science 369 : 397-403 (2020); PMID: 32703873
Cell Reports 33 : 108418 (2020); PMID: 33264628
Nature Communications 11 : 348 (2020); PMID: 31953436
Nature Communications 10 : 1495 (2019); PMID: 30940803
Nature Communications 9 : 4683 (2018); PMID: 30409970
Nature Communications 9 : 1223 (2018); PMID: 29581427
Cell Reports 18 : 3143-3154 (2017); PMID: 28355566
Molecular Cell 55 : 15-30 (2014), Cover Article; PMID: 24882209
Nature 493 : 689-93 (2013); PMID: 23334421
Nature Cell Biology 15 : 991-1000 (2013), Cover Article; PMID: 23811687
Nature Cell Biology 13 : 310-316 (2011), Cover Article; PMID: 21336310
Molecular Cell 37 : 668-678 (2010), Cover Article; PMID: 20227371
Qualifications
Applicants should have a strong publication record and relevant experience in areas such as molecular biology, biochemistry, cell biology, neuroscience, cancer biology, metabolism, stem cell biology, and animal models.
Application instructions
To apply, please send a cover letter, curriculum vitae, and contact information for three references to Professor Xiaolu Yang at xyang@pennmedicine.upenn.edu .
About the University of Pennsylvania
The University of Pennsylvania (Penn), a prestigious Ivy League institution, is globally recognized for its excellence in education, research, and innovation. Consistently ranked among the world’s top universities, Penn is home to the Perelman School of Medicine—the oldest and one of the most distinguished medical schools in the United States. The University, including the Perelman School of Medicine, is located on a vibrant urban campus that offers convenient access to a wide array of educational, cultural, and recreational opportunities.
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